涂晓明

2010-06-30来源:中科大生命科学院

博士,副教授,博导,入选国家教育部“新世纪优秀人才支持计划”。

1993年至2002年就读于中国科技大学生命科学学院并先后获学士,硕士和博士学位。2002年8月至2005年7月在美国加州大学旧金山分校从事博士后研究。2005年7月作为中国科技大学优秀人才引进,现为生命科学学院副教授。共发表论文22篇,其中以第一作者或通讯作者在Molecular Biology of the Cell、Journal of Cell Science、Journal of Biological Chemistry,Biochemical Journal等重要国际学术期刊发表研究论文14篇。

 

主要研究兴趣:

1.锥体虫细胞周期调控的分子机制研究(国家自然科学基金项目,中科院创新项目子课题)

2.Ubiquitin家族蛋白的结构和功能的研究(国家自然科学基金项目)

3.重要蛋白或蛋白结构域的结构和功能的研究(973子课题、863)

 
代表性论文:
1.Shanhui Liao, Tao Wang, Kai Fan and Xiaoming Tu** (2010) The small ubiquitin like modifier is essential in regulating mitosis in Trypanosoma brucei. Experimental Cell Research. In press. (**corresponding author)
2.Shanhui Liao, Qiang Shang, Xuecheng Zhang, Jiahai Zhang, Chao Xu, Xiaoming Tu** (2009) Pup, a prokaryotic ubiquitin-like protein, is an intrinsically disordered protein. Biochemical Journal. Accelerated Publication. 422: 207-215.
3.Wen Zhang, Jiahai Zhang, Chao Xu, Tao Wang, Xuecheng Zhang, Xiaoming Tu** (2009) Solution structure of Urm1 from Trypanosomabrucei. Proteins: Structure, Function, and Bioinformatics. 75:781-785.
4.Qiang Shang, Cao Xu, Jiahai Zhang, Xuechen Zhang, Xiaoming Tu** (2009) Solution Structure of SUMO from Trypanosoma brucei and Its Interaction with Ubc9. Proteins: Structure, Function, and Bioinformatics . 76:266-269.
5.Wen Zhang, Husheng Ding, Jiahai Zhang and Xiaoming Tu** (2008) 1H, 13C and 15N resonance assignment of Urm1 from Trypanosoma brucei. Biomolecular NMR Assignments. 2:59-60.
6.Qiang Shang, Lin Lin, Jiahai Zhang and Xiaoming Tu** (2007) 1H, 13C and 15N resonance assignment of truncated SUMO from Trypanosoma brucei. Biomolecular NMR Assignments. 1: 103-104.
7.Ziyin Li*, Xiaoming Tu* and Ching C. Wang (2006) Okadaic acid overcomes the blocked cell cycle caused by depleting Cdc2-related kinases in Trypanosoma brucei. Exp. Cell Res. 312:3504-3516.(*contributed equally)
8.Xiaoming Tu, Praveen Kumar, Ziyin Li and Ching C. Wang (2006) An Aurora Kinase Homologue is Involved in Mitosis and Cytokinesis in Trypanosoma brucei. J. Biol. Chem. 281:9677-9687.
9.Xiaoming Tu, Joel Mancuso, W. Zacheus Cande and Ching C. Wang (2005) Distinct Cytoskeletal Modulations and Mechanisms Regulating G1/S Transition between Two Life Stages of Trypanosoma brucei Cytoskeletal. Journal of Cell Science. 118:4353-4364.
10.Xiaoming Tu and Ching C. Wang (2005) Pairwise Knockdowns of cdc2-related Kinases (CRK) in Trypanosoma brucei Identified the CRKs for G1/S and G2/M Transitions and Demonstrated Distinctive Cytokinetic Regulations between Two Developmental Stages of the Organism. Eukaryotic Cell. 4:755-764.
11.Xiaoming Tu and Ching C. Wang (2005) Coupling of Posterior Cytoskeletal Morphogenesis to the G1/S Transition in the Trypanosoma brucei Cell Cycle. Molecular Biology of the Cell. 16:97-105.
12.Xiaoming Tu and Ching C. Wang (2004) The involvement of two cdc2-related kinases (CRKs) in Trypanosoma brucei cell cycle regulation and the distinctive stage-specific phenotypes caused by CRK3 depletion. J. Biol. Chem. 279:20519-20528.
13.Xiaoming Tu, Jihui Wu, Yingqi Xu and Yunyu Shi (2001) Letter to the Editor: 1H, 13C and 15N resonance assignments and secondary structure of ADR6 DNA-binding domain. J. Biomol. NMR. 21:187-188.
14.Xiaoming Tu, Yazhong Xiao, Wangyong Zeng and Yunyu Shi (2000) Expression and purification of a recombinant DNA-binding domain of ADR6 protein from Escherichia coli and its secondary structure characterization. Biochim. Biophys. Acta. 1481:167-174.
 
联系方式:xmtu@ustc.edu.cn

联系电话:63600757(办公室) 63600627(实验室)

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