陈 泉

2011-03-31来源:中科大生命科学院

博士,副教授。2007年毕业于中国科学技术大学生物化学与分子生物学系,获理学博士学位。2007至2009年赴美国梅奥医学院( Mayo Clinic)从事博士后工作,研究G蛋白偶联受体的结构和功能。2009至2011年赴南加州大学从事锌指蛋白的设计与筛选相关研究。2011年3月作为中国科技大学优秀人才引进,现任生命科学学院副教授。主要研究成果发表于Nature Communications, Journal of Biological Chemistry, Am. J. Physiol. Endocrinol. Metab, Protein Science等相关领域国际重要期刊。


主要研究兴趣:
开发设计生物网络适配的生物功能器件并探究其在合成生物学中的应用


代表性论文:
1. Xiong, P., Wang, M., Zhou, X., Zhang, T., Zhang, J., Chen, Q.*, Liu, H.*. Protein design with a comprehensive statistical energy function and boosted by experimental selection for foldability. Nature Communications, 2014, 5:5330
2. Miller, L.J., Chen, Q., Lam, P.C., Pinon, D.I., Sexton, P.M., Abagyan, R. and Dong, M.Refinement of glucagon-like peptide 1 docking to its intact receptor using mid-region photolabile probes and molecular modeling. Journal of Biological Chemistry, 2011, 286:15895-15907
3. Chen, Q., Pinon, D.I., Miller, L.J., and Dong, M. Spatial approximations between residues 6 and 12 in the amino-terminal region of glucagon-Like peptide 1 and its receptor. a region critical for biological activity. Journal of Biological Chemistry, 2010, 285: 24508-24518
4. Chen, Q., Miller, L.J., and Dong, M. Role of N-linked glycosylation in biosynthesis, trafficking, and function of the human glucagon-like peptide 1 receptor. Am. J. Physiol. Endocrinol. Metab. 2010, 299(1): E62-8
5. Chen, Q., Pinon, D.I., Miller, L.J., and Dong, M. Molecular basis of glucagon-like peptide 1 docking to its intact receptor studied with carboxyl-terminal photolabile probes. Journal of Biological Chemistry, 2009, 284: 34135-34144
6. Chen, Q., Niu, X., Xu, Y., Wu, J., and Shi, Y. Solution Structure and Backbone Dynamics of AF-6 PDZ domain/Bcr Peptide Complex. Protein Science, 2007, 16: 1053 - 1062
7. Niu, X., Chen, Q., Zhang, J., Shen, W., Shi, Y., and Wu, J. Interesting structural and dynamical behaviors exhibited by the AF-6 PDZ domain upon Bcr peptide binding. Biochemistry, 2007, 46(51):15042-15053
8. Ding, H., Xu, Y., Chen, Q., Dai, H., Tang, Y., Wu, J., and Shi, Y. Solution structure of human SUMO-3 C47S and its binding surface for Ubc9. Biochemistry, 2005, 44(8): 2790-2799
9. Zhang, X., Zhang, J., Li, X., Xu, J., Huang, H., Chen, Q., Wu, J., and Shi, Y. Compact molten globule-like state of hUBF HMG Box1 at extremely low pH. Biochimica et Biophysica Acta, 2005, 1748: 66–73
10. Chen, Q. and Shi, Y. Progress in SUMO modification research. Chinese Bulletin of Life Sciences, 2004, 16: 1-6
11. Xiao, Y., Chen, Q., Hang, J., Shi, Y., Wu, J., Hong, Y. and Wang, Y. Selective induction, purification and characterization of a laccase isozyme from the basidiomycete Trametes sp. AH28-2. Mycologia, 2004, 96(1):26-35


联系方式:
Email: chenquan@ustc.edu.cn
电话:63607450

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