薛 天

2021-05-04来源:生命科学学院



博士 教授 博导 中国科学技术大学人力资源部部长 生命科学与医学部执行部长  微尺度物质科学国家研究中心“神经环路与脑认知部主任 长期从事光感受神经生物学的光信号转导、神经环路以及视觉再生修复等方面研究

至今共发表SCI论文49篇,多篇通讯作者论文发表在NatureCell等学术期刊,引用4000余次, h-index 27获国家创新人才计划(2012),优秀青年基金 (2013),重大科学研究计划青年973项目首席科学家(2013),中科院脑科学卓越中心骨干(2014),国际研究资助组织Human Frontier Science Program (HFSP) Young Investigator Grants(2014),国家自然科学基金委杰出青年基金(2019),国家重点研发计划项目首席科学家(2020。担任国务院学术委员会第八届学科评议组成员、教育部高等学校生物技术与生物工程类专业教学指导委员会委员中国生理学会常务理事中国神经科学学会、中国细胞生物学学会理事中国生物物理学会组织建设工作委员会主任等学术任职


教育和研究经历

1995-2000年, 中国科学技术大学少年班系(强化班),获学士学位

2000-2005年, 美国约翰霍普金斯大学医学院,获分子生理学博士学位

2006-2011年, 美国约翰霍普金斯大学医学院神经学系,博士后

2011-2012年, 美国约翰霍普金斯大学医学院神经学系,助理研究员

2012年至今,  合肥微尺度物质科学国家研究中心,教授

2012年至今,  中国科学技术大学生命科学学院,教授

 

获奖情况:

1.   2003      American Heart Association (AHA) Scientific Sessions Selected  Late-Breaking Science

2.   2004      NIH Stem Cells Scholarship at the Keystone Stem Cells Symposium, NIH

3.   2006      BEST BASIC SCIENCE PAPER by Circulation, AHA  

4.   2007      Final list of Life Science Research Foundation Fellowships  

5.   2012      国家创新人才计划

6.   2013      国家自然科学基金委优秀青年基金

7.   2014      Human Frontier Science Program (HFSP)Young Investigator Grants

8.   2019      2019年度中国生命科学十大进展

9.   2019      Cell杂志2019年最佳论文

10. 2019      国家自然科学基金委杰出青年基金

11. 2020      2020年度“中国神经科学重大进展”

 

学术任职:

2020-至今   国务院学术委员会第八届学科评议组成员

2019-至今   教育部生物技术与生物工程教学指导委员会,委员

2019-至今   中国医师协会眼科医师分会基础与临床转化专委会,委员

2019-至今   中国神经科学学会理事

2018-至今   海峡两岸医药卫生交流协会眼科专委会眼干细胞学组,副组长

2018-至今   中国生理学会,常务理事

2018-至今   中国生物物理学会“组织建设工作委员会主任委员

2015-至今   中国细胞生物学学会,理事

2015-至今   安徽省细胞生物学会,副理事长

  

主要研究兴趣:

光是生命之源。生物体的光感知系统不仅提供视觉能力,还调控机体一系列重要的生理功能,一旦受损则会造成严重的视觉疾病。就“光与生命这一主题,薛天教授主要进行以下方面的研究

1、生命体如何感光-光感受的信号转导机制,特别是自感光视网膜神经节细胞(ipRGCs)的光信号转导机制。

2、光调控生命体生理功能-非成像视觉神经环路,如夜间异常光诱发抑郁样表型的神经环路结构与功能

3、探索基因编辑、干细胞技术和纳米新材料在大动物模型中治疗视网膜感光细胞退化疾病中的应用。如结合视觉神经生物医学与纳米技术,首次实现哺乳动物裸眼红外图像视觉;对于视觉神经系统遗传性疾病,采用在体同源重组的基因编辑技术,挽救感光细胞退化小鼠视觉;解析人类与非人灵长类恒河猴视网膜衰老分子图谱;建立首例非人灵长类视网膜色素变性猕猴模型等。

 

相关科研成果报道

亚搏APP手机版首次解析人类与非人灵长类恒河猴视网膜衰老分子图谱

亚搏APP手机版在夜间光诱导负性情绪研究方面取得进展

亚搏APP手机版在基因编辑视网膜感光细胞治疗遗传性致盲疾病中取得进展

亚搏APP手机版在实现哺乳动物裸眼红外图像视觉上取得进展 


发表论文:

1.     Yi WY#, Lu YF#, Zhong SJ#, Zhang M#*, Sun L, Dong H, Wang MD, Wei M, Xie HH, Qu HQ, Peng RM, Hong J, Yao ZQ,Tong YY,Wang W, Ma Q, Liu ZY, Ma YQ, Li SZ, Yin CH, Liu JW, Ma C, Wang XQ*,Wu Q*, and Xue T*† (2020). A single-cell transcriptome atlas of the aging human and macaque retina, National Science Review. In press. (# equal contributions, *co-corresponding authors,†lead contact)

2.    Li SZ#, Hu YZ#, Li YQ#, Hu M, Wang WC, Ma YQ, Cai Y, Wei M, Yao YC, Wang Y, Dong K, Gu YH, Zhao H, Bao J, Qiu ZL, Zhang M*, Hu XT*, Xue T*(2020). Generation of nonhuman primate retinitis pigmentosa model by in situ knockout of RHO in rhesus macaque retina. Science Bulletin. In press.

3.    Cheng P#, Tian X#, Tang W, Cheng J, Bao J, Wang H, Zheng S, Wang Y, Wei X, Chen T, Feng H, Xue T, Goda K, and He H. (2021). Direct control of store-operated calcium channels by ultrafast laser. Cell Res. In press.

4.     Huang X#, Huang P#, Huang L#, Hu Z, Liu X, Shen J, Xi Y, Yang Y, Fu Y, Tao Q, Lin S, Xu A, Xu F, Xue T, So KF*, Li H*, and Ren C* (2021). A Visual Circuit Related to the Nucleus Reuniens for the Spatial-Memory-Promoting Effects of Light Treatment. Neuron 109, 347-362 e347.

5.    Li X#, Zhang J#*, Li D, He C, He K, Xue T, Wan L, Zhang C, and Liu Q*. (2021). Astrocytic ApoE reprograms neuronal cholesterol metabolism and histone-acetylation-mediated memory. Neuron. In press.

6.    Liu Q#, Su LY#*, Sun C, Jiao L, Miao Y, Xu M, Luo R, Zuo X, Zhou R, Zheng P, Xiong W, Xue T, and Yao YG* (2020).        Melatonin alleviates morphine analgesic tolerance in mice by decreasing NLRP3 inflammasome activation. Redox Biol 34, 101560.

7.  An K#, Zhao H#*, Miao Y, Xu Q, Li YF, Ma YQ, Shi YM, Shen JW. Meng JJ, Yao YG, Zhang Z, Chen JT, Bao J, Zhang M and Xue T*† (2020). A Circadian Rhythm-gated Subcortical Visual Circuit for Nighttime Light Induced Depressive-like Behaviors, Nat. Neurosci.23, 869-880.

7.    Lu Y#, Shiau F#, Yi W#, Lu S, Wu Q, Pearson J, Kallman A, Zhong S, Hoang T, Zuo Z, Zhao F, Zhang M, Tsai N, Zhuo Y, He S, Zhang J, Stein-O’Brien G, Sherman T, Duan X, Fertig D, Goff L, Zack J, Handa J, Xue T*, Bremner R*, Blackshaw S*,Wang X* and Clark B*† (2020). Single-cell analysis of human retina identifies evolutionarily conserved and species-specific mechanisms controlling development. Dev. Cell. 53, 473-491.

8.     Xie H#, Zhang W#, Zhang M#*, Akhtar T, Li Y, Yi W, Sun X, Zuo Z, Wei M, Fang X, Yao Z, Dong K, Zhong S, Liu Q, Shen Y, Wu Q, Wang X, Zhao H, Bao J, Qu K*, Xue T*† (2020). Chromatin accessibility analysis reveals regulatory dynamics of developing human retina and hiPSC derived retinal organoids. Sci. Adv. 6, eaay5247. 

9.   Akhtar T, Xie H, Khan MI, Zhang M*, Xue T*† (2019). Accelerated photoreceptor differentiation of hiPSC-derived retinal organoids by contact co-culture with retinal pigment epithelium, Stem Cell Res., 39, 101491.

10.   Ma Y#, Bao J#*, Zhang Y#, Li Z, Zhou Z, Zhou X, Wan C, Huang L, Zhao Y, Han G*, Xue  T*† (2019). Mammalian Near-Infrared Image Vision through Injectable and Self-Powered Retinal Nanoantennae. Cell 177, 243-255 e215. Cell Best of 2019, Cell press (9 Best Articles which published in Cell in 2019)

11.   Cai Y#, Cheng T#, Yao Y#, Li X, Ma Y, Li L, Zhao H, Bao J, Zhang M*, Qiu Z*, Xue T*†  (2019). In vivo genome editing rescues photoreceptor degeneration via a Cas9/RecA-mediated homology-directed repair pathway. Sci Adv 5, eaav3335.


12.   Yu N, Huang L, Zhou Y*, Xue T*, Chen Z*, and Han G* (2019). Near-Infrared-Light Activatable Nanoparticles for Deep-Tissue-Penetrating Wireless Optogenetics. Adv Healthc Mater, e1801132. (review)


13.   Huang L, Xi Y, Peng Y, Yang Y, Huang X, Fu Y, Tao Q, Xiao J, Yuan T, An K, Zhao H, Pu M, Xu F, Xue T, Luo M, So KF, Ren C (2019). A Visual Circuit Related to Habenula Underlies the Antidepressive Effects of Light Therapy. Neuron 102, 128-142 e128.

14.   Zhu H#, Wang N#, Yao L, Chen Q, Zhang R, Qian J, Hou Y, Guo W, Fan S, Liu S, Zhao Q, Du F, Zuo X, Guo Y, Xu Y, Li J, Xue T, Zhong K, Song X, Huang G*, Xiong W* (2018). Moderate UV exposure enhances learning and memory by promoting a novel glutamate biosynthetic pathway in the brain. Cell 173, 1716-1727 e1717.


15.  Ye F, Huang Y, Li J, Ma Y, Xie C, Liu Z, Deng X, Wan J, Xue T, Liu W, Zhang M (2018). An unexpected INAD PDZ tandem-mediated plcbeta binding in Drosophila photo receptors. Elife 7.


16.   Deng K, Shen J, Wang W, Li M, Li H, Chen C, Zhao H, Zhang M, Xue T, Liu Q, Lui VWY, Hong B*, Lin W* (2018). Sodium chloride (NaCl) potentiates digoxin-induced anti-tumor activity in small cell lung cancer. Cancer biology & therapy 20, 52-64.


17.   Deng WL, Gao ML, Lei XL, Lv JN, Zhao H, He KW, Xia XX, Li LY, Chen YC, Li YP, Pan D, Xue T, Jin, Z. B (2018). Gene Correction Reverses Ciliopathy and Photoreceptor Loss in iPSC-Derived Retinal Organoids from Retinitis Pigmentosa Patients. Stem Cell Rep.10,1267-1281.


18.   Tang J, Qin N, Chong Y, Diao Y, Yiliguma, Wang Z, Xue T, Jiang M, Zhang J*, Zheng G* (2018). Nanowire arrays restore vision in blind mice. Nat. Commun. 9, 786.


19. Cheng J, Huang X, Liang Y, Xue T, Wang L*, Bao J* (2018). Plasticity of Light-induced Concurrent Glutamatergic and GABAergic Quantal Events in the Suprachiasmatic Nucleus. J Biol Rhythms 33, 65-75.


20.   Huang DF, Wang MY, Yin W, Ma YQ, Wang H, Xue T, Ren DL*, and Hu B*. (2018). Zebrafish Lacking Circadian Gene per2 Exhibit Visual Function Deficiency. Front Behav Neurosci 12, 53.


21.   Li Q, Cui M, Yang F, Li N, Jiang B, Yu Z, Zhang D, Wang Y, Zhu X, Hu H, Li PS, Ning SL, Wang S, Qi H, Song H, He D, Lin A, Zhang J, Liu F, Zhao J, Gao L, Yi F, Xue T, Sun JP, Gong Y, Yu X(2017). A cullin 4B-RING E3 ligase complex fine-tunes pancreatic δ cell paracrine interactions. J Clin Invest. 127, 2631-2646.


22.  Wang Q, Yue WWS, Jiang Z, Xue T, Kang SH, Bergles DE, Mikoshiba K, Offermanns S, Yau KW (2017). Synergistic Signaling by Light and Acetylcholine in Mouse Iris Sphincter Muscle. Curr Biol. 27, 1791-1800.


23.   Liu CH, Gong Z, Liang ZL, Liu ZX, Yang F, Sun YJ, Ma ML, Wang YJ, Ji CR, Wang YH, Wang MJ, Cui FA, Lin A, Zheng WS, He DF, Qu C, Xiao P, Liu CY, Thomsen ARB, Joseph Cahill T, Kahsai AW, Yi F, Xiao KH, Xue T, Zhou Z, Yu X, Sun JP (2017). Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling. Nat. Commun. 8, 14335.


24.   Wen M, Guo X, Sun P, Xiao L, Li J, Xiong Y, Bao J, Xue T, Zhang L, Tian C (2015). Site-specific fluorescence spectrum detection and characterization of hASIC1a channels upon toxin mambalgin-1 binding in live mammalian cells. Chem Commun (Camb)  51, 8153-6.


25.   Hu QX, Dong JH, Du HB, Zhang DL, Ren HZ, Ma ML, Cai Y, Zhao TC, Yin XL, Yu X, Xue T, Xu ZG, Sun JP (2014). Constitutive Gαi Coupling Activity of VLGR1 and its Regulation by PDZD7. J Biol Chem 289, 24215-2


26. Zhong X, Gutierrez C, Xue T, Hampton C, Vergara MN, Park T, Zambidis E, Meyer J, Gamm MD, Yau KW, Canto-Soler MV (2014). Generation of three dimensional retinal tissue with functional photoreceptors from human iPSCs. Nat. Commun. 5, 4047.


27.   Welsbie DS, Yang Z, Ge Y, Mitchell KL, Zhou X, Martin SE, Berlinicke CA, Hackler L Jr, Fuller J, Fu J, Cao LH, Han B, Auld D, Xue T, Hirai SI, Germain L, Simard-Bisson C, Blouin R, Nguyen JV, Davis CH, Enke RA, Boye SL, Merbs SL, Marsh-Armstrong N, Hauswirth WW, Diantonio A, Nickells RW, Inglese J, Hanes J, Yau KW, Quigley HA, Zack DJ (2013). Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death. PNAS 110, 4045-50.


28.   Pearson RA, Barber AC, Rizzi M, Hippert C, Xue T, West EL, Duran Y, Smith AJ, Chuang JZ, Azam SA, Luhmann UFO, Benucci A, Sung CH, Carandini M, Yau KW, Sowden JC, Ali RR (2012). Restoration of vision after transplantation of photoreceptors. Nature 485, 99-103.


29.   Xue T*, Do MT, Riccio A, Jiang Z, Hsieh J, Wang HC, Merbs SL, Welsbie DS, Yoshioka T, Weissgerber P, Stolz S, Flockerzi V, Freichel M, Simon MI, Clapham DE, Yau KW* (2011). Melanopsin Signaling in Mammalian Iris and Retina. Nature 479, 67-73. (Faculty of 1000:  f1000.com/13360986).


30.   Do MT, Kang SH, Xue T, Zhong H, Liao HW, Bergles DE, Yau KW (2009) Photon capture and signalling by melanopsin retinal ganglion cells. Nature 457, 281-7. (Faculty of 1000:  f1000.com/1144855).


31.   Luo DG, Xue T, Yau KW (2008) How vision begins: An odyssey. PANS 105, 9855-62  (review)

32.   Fu YB#, Kefalov V#, Luo DG#, Xue T#, Yau KW (2008). Quantal noise from human red cone pigment. Nat. Neurosci. 11, 565-71


33.   Xue T, Siu CW, Lieu DK, Lau CP, Tse HF, Li RA (2007). Mechanistic role of I(f) revealed by induction of ventricular automaticity by somatic gene transfer of gating-engineered pacemaker (HCN) channels. Circulation 115, 1839-1850.


34.   El-Kholy W, MacDonald PE, Fox JM, Bhattacharjee A, Xue T, Gao X, Zhang Y, Stieber J, Li RA, Tsushima RG, Wheeler MB. (2007) Hyperpolarization-activated cyclic nucleotide-gated channels in pancreatic beta-cells. Mol. Endocrinol. 21, 753-764.


35.   Tse HF, Xue T, Lau CP, Siu CW, Wang K, Zhang QY, Tomaselli GF, Akar FG, Li RA (2006).  A bio-artificial sinus node constructed via in vivo gene transfer of an engineered pacemaker (HCN) channel reduces the dependence on electronic pacemaker in a sick sinus syndrome model.  Circulation 114, 1000-1011. Issue highlights, GROUND-BREAKING STUDY OF 2007 AHA.


36.  Ardehali H, Xue T, Dong P, Machamer C (2005).  Targeting of the mitochondrial membrane proteins to the cell surface for functional studies.  Biochem Bioph Res Comm. 338, 1143-51.


37.  Abraham MR, Henrikson CA, Tung L, Chang MG, Aon M, Xue T, Li RA, O'Rourke B, Marban E (2005).  Antiarrhythmic engineering of skeletal myoblasts for cardiac transplantation.  Circ Res. 97, 159-67.


38.   Moore JC, van Laake LW, Braam SR, Xue T, Tsang SY, Ward D, Passier R, Tertoolen LL, Li RA, Mummery CL (2005). Human embryonic stem cells: Genetic manipulation on the way to cardiac cell therapies. Reprod Toxicol. 20, 377-91.


39.   Azene EM, Xue T, Marban E, Tomaselli GF, Li RA (2005).  Non-equilibrium behavior of HCN channels: Insights into the role of HCN channels in native and engineered pacemakers.  Cardiovasc Res. 67, 263-73.

40.   Wang G#, Xue T#, Tsang SY, Wong J, Cheng L, Zhang J, Li GR, Lau CP, Li RA, Tse HF (2005).  Electrophysiological properties of pluripotent human and mouse embryonic stem cells.  Stem Cells 23, 1526-34. 

41.   Xue T#, Cho H#, Akar F#, Tsang SY, Jones S, Marbán E, Tomaselli GF, Li RA (2005).  Functional Integration of Electrically Active Cardiac Derivatives from Genetically Engineered Human Embryonic Stem Cells with Quiescent Recipient Ventricular Cardiomyocytes. Insights into the Development of Cell-Based Pacemakers.  Circulation 11, 111-20. Issue highlights, Best Paper Award, Circulation 2005


42.   Xue T, Sato K, Kodama K, Ennis I, French RJ, Li RA (2003).  Novel interactions identified between µ-conotoxin and the  Na+ channel Domain I P-loop: Implications for toxin-pore binding geometry.  Biophys. J. 85, 2299-310.

43.   Azene EM#, Xue T#, Li RA (2003).  Molecular basis of the effects of potassium on heterologously-expressed pacemaker (HCN) channels.  J. Physiol. 547, 349-356.


44. Henrikson CA, Xue T, Dong P, Sang D, Marbán E, Li RA (2003).  Identification of a surface charged residue in the S3-S4 linker of pacemaker (HCN) channel that influences activation gating.  J. Biol. Chem. 278, 13647-54.


45.   Li RA, Ennis I, Xue T, Nguyen HM, Tomaselli GF, Goldin AL, Marbán E (2003).  Molecular basis of isoform-specific µ-conotoxin block of cardiac, skeletal muscle and brain Na channels. J. Biol. Chem. 278, 8717-24.


46.  Xue T, Li RA (2002). An external determinant in the S5-P linker of the pacemaker (HCN) channel identified by sulfhydryl modification. J. Biol. Chem. 277, 46233-42.


47.  Xue T, Marbán E, Li RA (2002). Dominant-negative suppression of HCN1- and HCN2-encoded pacemaker currents by an engineered HCN1 construct: Insights into structure-function relationships and multimerization.  Circ. Res. 90, 1267-1273.


48.   Li RA, Sato K, Kodama K, Kohno T, Xue T, Tomaselli GF, Marban E. (2002). Charge conversion enables quantification of the proximity between a normally-neutral mu-conotoxin (GIIIA) site and the Na+ channel pore. FEBS Lett. 511, 159-164.

 

 招生招聘:

实验室招聘神经生物学(电生理)、干细胞和分子生物学等相关背景的博士后和特任(副)研究员,待遇从优。同时热忱欢迎对本实验室研究方向感兴趣的本科生前来攻读博士学位。

 

联系方式: xuetian@)ustc.edu.cn

联系电话: 63600971

实验室网页:javascript:;  (光与生命实验室)

Researcher ID : javascript:;

 

 

 
上一篇:下一篇: