江永亮

2018-03-01来源:生命科学学院


博士、中国科学技术大学副教授2007年毕业于合肥工业大学生物技术专业获得理学学士学位,2012年毕业于中国科学技术大学生物化学与分子生物学专业获得理学博士学位。20126月在中国科学技术大学生命科学学院工作,先后从事博士后研究和担任特任副研究员。20181月通过中国科学技术大学优秀人才引进,受聘为生命科学学院副教授。主要研究方向为生物大分子结构和功能。研究成果以第一作者身份发表于PNASNature CommunicationsPLoS PathogensJBC等国际著名期刊上。获首届中国科协青年人才托举工程资助。

主要研究兴趣:
1.蓝细菌碳氮代谢协同调控的分子机理。
2.蓝细菌代谢相关重要蛋白质复合物的结构生物学研究。

3.细菌重要膜转运蛋白的结构和功能研究。

  

代表性学术论文:*通讯作者, #相同贡献)

  1. Jiang YL#, Wang XP#, Sun H#, Han SJ, Li WF, Cui N, Lin GM, Zhang JY, Cheng W, Cao DD, Zhang ZY, Zhang CC*, Chen Y*, Zhou CZ*. Coordinating carbon and nitrogen metabolic signaling through the cyanobacterial global repressor NdhR. Proc Natl Acad Sci U S A.115(2):403-408. 2018

  2. Yang HB#, Hou WT#, Cheng MT#, Jiang YL*, Chen Y*, Zhou CZ*. Structure of a MacAB-like efflux pump from Streptococcus pneumoniae.Nature Communications.9(1):196. 2018

  3. Jiang YL#, Jin H#, Yang HB, Zhao RL, Wang SL, Chen Y*, Zhou CZ*. Defining the enzymatic pathway for polymorphic O-glycosylation of thepneumococcalserine-rich repeat protein PsrP. J Biol Chem. 292(15):6213-6224. 2017

  4. Yang YH#, Jiang YL#, Zhang J, Wang L, Bai XH, Zhang SJ, Ren YM, Li N, Zhang YH, Zhang Z, Gong Q, Mei Y, Xue T, Zhang JR, Chen Y*, Zhou CZ*. Structural insights into SraP-mediated Staphylococcus aureus adhesion to host cells.PLoS Pathogens. 10(6): e1004169. 2014.

  5. Shi WW#,Jiang YL#, Zhu F, Yang YH, Shao QY, Yang HB, Ren YM, Wu H*, Chen Y*, Zhou CZ*. Structure of a novel O-GlcNAc transferase GtfA reveals insights into the glycosylation of pneumococcal serine-rich repeat adhesins.J Biol Chem. 289(30):20898-20907. 2014.

  6. Zhang J#, Yang YH#,Jiang YL*, Zhou CZ, Chen Y*. Structural and biochemical analyses of Streptococcus pneumoniae L,D-carboxypeptidase DacB.Acta Crystallographica Section D. 71(Pt):283-292. 2015.

  7. Wang L,Jiang YL*, Zhang JR, Zhou CZ, Chen Y*. Structural and enzymatic characterization of the choline kinase LicA from Streptococcus pneumoniae.PLoS One. 10(3): e0120467. 2015.

  8. Lu M#,Jiang YL#,*, Wang S#, Jin H, Zhang RG, Virolle MJ, Chen Y, Zhou CZ*. Streptomyces coelicolor SCO4226 is a nickel binding protein.PLoS One. 9(10):e109660. 2014

  9. Hou WT, Li WZ, Chen Y,Jiang YL*, Zhou CZ*. Structures of yeast Apa2 reveal catalytic insights into a canonical Ap4A phosphorylase of the histidine triad superfamily.J Mol Biol. 425(15):2687-98. 2013.

  10. Jiang YL, Yu WL, Zhang JW, Frolet C, Di Guilmi AM, Zhou CZ, Vernet T*, Chen Y*. Structural basis for the substrate specificity of a novel β-N-acetyl-hexosaminidase StrH protein from Streptococcus pneumoniae R6.J Biol Chem. 286(50):43004-12. 2011.

  11. Jiang YL, Zhang JW, Yu WL, Cheng W, Zhang CC, Frolet C, Di Guilmi AM, Vernet T, Zhou CZ*, Chen Y*. Structural and enzymatic characterization of a Streptococcal ATP/diadenosine polyphosphate and phosphodiester hydrolase Spr1479/SapH.J Biol Chem. 286(41):35906-14. 2011.

  12. Zhao MX#,Jiang YL#, Xu BY, Chen Y, Zhang CC, Zhou CZ*. Crystal structure of the cyanobacterial signal transduction protein PII in complex with PipX.J Mol Biol. 402(3):552-9. 2010.

  13. Zhao MX,Jiang YL, He YX, Chen YF, Teng YB, Chen Y, Zhang CC*, Zhou CZ* Structural basis for the allosteric control of the global transcription factor NtcA by the nitrogen starvation signal 2-oxoglutarate.Proc Natl Acad Sci U S A. 107(28):12487-92. 2010.


    联系方式:

0551-63600407

E-mail:jyl@ustc.edu.cn

  


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