张 璇

2020-01-14来源:生命科学学院



博士,副教授。2005年毕业于安徽大学,获理学学士。同年进入中国科学技术大学微尺度国家实验室硕博连读,于2010年获得理学博士学位。2011年至2015年在美国Cornell大学生物化学系从事博士后研究工作,20154月起任中国科学技术大学生命科学学院特任副研究员,20194月起任副教授。主要研究成果以(共)第一作者/通讯作者身份发表在Nature CommunicationsJACSPNASCell Research等期刊。


主要研究兴趣:

1)着丝粒-动粒的组装与调控机制

2) 组蛋白翻译后修饰的识别与调控机制

3)金黄色葡萄球菌致病机理

  

代表论文:

 (#)第一作者,(*)通讯作者

1.       Fang Tiantian (#), Chen Wanbiao (#), Sheng Yaping, Yuan Siming, Tang Qiaowei, Li Gongyu, Huang Guangming, Su Jihu, Zhang Xuan(*), Zang Jianye (*), Liu Yangzhong (*), Tetrathiomolybdate induces dimerization of the metal-binding domain of ATPase and inhibits platination of the protein, Nature Communications, 2019, 10:186

2.       Hang Tianrong (#), Chen Wanbiao (#), Wu Minhao, Zhan Li, Wang Chengliang, Jia Nan, Zhang Xuan(*), Zang Jianye (*),Structural insights into the molecular mechanism underlying Sirt5-catalyzed desuccinylation of histone peptides, Biochemical Journal, 2019, 476 (2):211-223

3.       Tian Tian (#) Li Xiaorun (#) Liu Yingying (#) Wang ChengliangLiu Xing; Bi Guoqiang; Zhang Xuan(*); Yao Xiaobiao (*) ; Zhou Z.Hong (*) ; Zang Jianye (*), Molecular basis for CENP-N recognition of CENP-A nucleosome on the human kinetochore, Cell Research, 2018,28: 374-378

4.       Zhou Xing (#)Zheng Fan(#)Wang Chengliang (#)Wu MinhaoZhang XiaozhenWang QianYao XuebiaoFu ChuanhaiZhang Xuan (*)Zang Jianye (*), Phosphorylation of CENP-C by Aurora B facilitates kinetochore attachment error correction in mitosis, Proceedings of the National Academy of Sciences of the United States of America, 2017.11, 114: E10667~E10676

5.        Zhang Yingjie (#), Wu Minhao (#), Hang Tianrong (#), Wang Chengliang, Yang Ye, Pan Wenmin, Zang Jianye, Zhang Min (*), Zhang Xuan (*)Staphylococcus aureus SdrE captures complement factor H's C-terminus via a novel 'close, dock, lock and latch' mechanism for complement evasionBiochemical Journal, 201747410):1619-1631

6.        Eser Bekir E (#)., Zhang Xuan (#)Chanani Prem K.Begley Tadhg P. (*)Ealick Steven E. (*) From Suicide Enzyme to Catalyst: The Iron-Dependent Sulfide Transfer in Methanococcus jannaschii Thiamin Thiazole Biosynthesis, Journal of the American Chemical Society, 2016, 138 (11)3639~3642

7.       Sasaki EitaZhang XuanSun He G.Lu Mei-Yeh JadeLiu Tsung-linOu AlbertLi Jeng-yiChen Yu-hsiangEalick Steven E.Liu Hung-wen *Co-opting sulphur-carrier proteins from primary metabolic pathways for 2-thiosugar biosynthesisNature2014.6.195107505):427~+

 

联系方式

邮箱:xuanzbin@ustc.edu.cn

Tel: 86 551 63603435

 


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