张 亮

2020-07-22来源:生命科学学院

  

  

张亮,博士,特任副研究员。2009年毕业于南开大学获信息安全专业学士学位,2014年毕业于南开大学获生物化学与分子生物学专业理学博士。随后先后在美国天主教大学和美国国立健康研究中心(NIH)从事博士后研究。201912月起加入中国科学技术大学生命科学学院施蕴渝院士团队,任特任副研究员。研究成果发表于Nature CommunicationsNucl. Acids ResBiochemical and Biophysical Research Communications等期刊。

 

研究兴趣:

线粒体核糖体的CryoET的结构研究

线粒体相关蛋白复合物,蛋白核酸复合物的功能与结构研究

 

代表论文#通讯作者, *共同一作

1.    Zhang L*, #, Wang H*, Liu X, Zhou W#, Rao Z. The crystal structure of the phosphotriesterase from M. tuberculosis, another member of phosphotriesterase-like lactonase family. Biochemical and Biophysical Research Communications. (2019). 510(2):224-229. doi: 10.1016/j.bbrc.2019.01.069. *co-first author and corresponding author

2.    Park J, Zhang L, Bang JK, Andresson T, DiMaio F, Lee KS. Phase separation of Plk4 by autoactivation and clustering drives centriole biogenesis. Nature Communications. (2019). 10(1):4959

3.    Kim TS*, Zhang L*, Ahn J*, Meng L, Chen Y, Lee E, Bang JK, Lim JM, Ghirlando R, Fan L, Wang Y, Kim BY, Park J, Lee KS. Molecular architecture of a cylindrical self-assembly at human centrosomes. Nature Communications. (2019). Accepted. *co-first author

4.    Gao S, Zhang L and Rao VB. Exclusion of small terminase mediated DNA threading models for genome packaging in bacteriophage T4. Nucl. Acids Res. (2016). 44(9):4425-39.

5.    Zhang L, Duan X, Zhou D, Dong Z, Ji K, Meng W, Li G, Li X, Yang H, Ma T and Rao Z. Structural insights into the stabilization of active, tetrameric DszC by its C‐terminus. Proteins: Structure, Function, and Bioinformatics. (2014). 82(10):2733-43.

6.    Zhao C, Lou Z, Guo Y, Ma M, Chen Y, Liang S, Zhang L, Chen S, Li X, Liu Y, Bartlam M and Rao Z. Nucleoside monophosphate complex structures of the endonuclease domain from the influenza virus polymerase PA subunit reveal the substrate binding site inside the catalytic center. J Virol. 2009 Sep;83(18):9024-30

 

邮箱:zhangl99@ustc.edu.cn

手机:13820322653

实验室网址:javascript:;

 


上一篇:下一篇: